Platelet clumping is most commonly caused by pre-analytic errors such as improper or delayed sample mixing, clotted sample, over-filled or underfilled tubes, and time delay between sample collection and testing. It can also be an ex vivo phenomenon due to EDTA-dependent antibodies.
- Why do platelets clump on CBC?
- How common is platelet clumping?
- What is the clumping of platelets called?
- What is the effect of excess EDTA on platelets count?
- What does it mean if your platelets are clumping?
- What do platelet clumps indicate?
- How common is Pseudothrombocytopenia?
- Is platelet clumping serious?
- Why would platelets clump together?
- Are platelet clumps normal?
Why do platelets clump on CBC?
Platelet clumping is most commonly caused by pre-analytic errors such as improper or delayed sample mixing, clotted sample, over-filled or underfilled tubes, and time delay between sample collection and testing. It can also be an ex vivo phenomenon due to EDTA-dependent antibodies.
How common is platelet clumping?
Results: Thrombocytopenic patients with viral infection had a higher frequency of platelet clumping than those with other diseases, which was statistically significant (13.8% vs. 6.5%, respectively: P = 0.003).
What is the clumping of platelets called?
Introduction: PseudothrombocytopeniaPseudothrombocytopeniaPseudothrombocytopenia or spurious thrombocytopenia is an in-vitro sampling problem which may mislead the diagnosis towards the more critical condition of thrombocytopenia. The phenomenon occurs when the anticoagulant used while testing the blood sample causes clumping of platelets which mimics a low platelet count.https://en.wikipedia.org › wiki › PseudothrombocytopeniaPseudothrombocytopenia - Wikipedia (PTCP) is the phenomenon of ethylenediaminetetraacetic acid anticoagulant-activated platelet clumping, which results in artificially low platelet countslow platelet countsThrombocytopenia is a condition that occurs when the platelet count in your blood is too low. Platelets are tiny blood cells that are made in the bone marrow from larger cells. When you are injured, platelets stick together to form a plug to seal your wound.https://www.nhlbi.nih.gov › health › thrombocytopeniaPlatelet Disorders - Thrombocytopenia | NHLBI, NIH.
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What is the effect of excess EDTA on platelets count?
It inhibits clotting by removing or chelating calcium from the blood. EDTA most important advantage is that it does not distort blood cells, making it ideal for the most hematological tests. It is known to cause erroneous results of platelet counts by automated hematological analysers yielding low plateletslow plateletsThrombocytopenia is a condition that occurs when the platelet count in your blood is too low. Platelets are tiny blood cells that are made in the bone marrow from larger cells. When you are injured, platelets stick together to form a plug to seal your wound.https://www.nhlbi.nih.gov › health › thrombocytopeniaPlatelet Disorders - Thrombocytopenia | NHLBI, NIH counts.
What does it mean if your platelets are clumping?
Platelet clumping occurs when the blood platelets responsible for coagulation stick to one another to form clusters. The presence of platelet clumping has no clinical consequences other than preventing instruments from properly counting blood platelets.
What do platelet clumps indicate?
The presence of platelet clumps on blood smear, whether platelet count is normal or low, has no clinical significance and does not represent a disease. The most common cause of platelet clumping in blood is ethylenediaminetetra-acetic acid (EDTA), the anticoagulant used in test tubes for complete blood counts.
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How common is Pseudothrombocytopenia?
Pseudothrombocytopenia may also result from in vitro platelet adherence (“satellitism”) to leukocytes. These phenomena are identified by examination of the peripheral blood film (Fig. 8.1). Pseudothrombocytopenia occurs in approximately 1 in 1000 people and is not clinically significant.
Is platelet clumping serious?
The presence of platelet clumping has no clinical consequences other than preventing instruments from properly counting blood platelets.
Pseudothrombocytopenia Due To Platelet Clumping
Why would platelets clump together?
Platelet clumping is most commonly caused by pre-analytic errors such as improper or delayed sample mixing, clotted sample, over-filled or underfilled tubes, and time delay between sample collection and testing. It can also be an ex vivo phenomenon due to EDTA-dependent antibodies.
Are platelet clumps normal?
Platelet clumping is a common laboratory phenomenon that complicates or precludes reporting of platelet count. It is often, but not always, a phenomenon commonly caused by the anticoagulant EDTA.