Overexpression of HER2 with IHC without gene amplification may be due to high polysomy of chromosome 17 or may occur through various molecular epigenetic or posttranscriptional events (e.g., DNA hypomethylation in the promoter regions, posttranscriptional events) .
- What causes HER2 overexpression in breast cancer?
- How does HER2 breast cancer develop?
- Where does HER2-positive come from?
- What causes amplification of the HER2 gene?
- Where does HER2-positive breast cancer come back?
- Does HER2-positive come back?
- Does HER2-positive mean metastatic?
- Is HER2 breast cancer curable?
- Where does HER2 occur?
- What is the survival rate of HER2-positive breast cancer?
What causes HER2 overexpression in breast cancer?
High levels of HER2 protein are encountered due to overexpression caused by a mutation in the HER2 gene. HER2 produced at high levels causes uncontrolled proliferation of cells.
How does HER2 breast cancer develop?
In about 25 percent of breast cancers, the cancer cells have an excess of the HER2 protein. This is caused by a mutation in the HER2 (human epidermal growth factor receptor 2) gene. When the HER2 gene mutates, it causes cells in the breast to grow and divide at an uncontrolled rate, leading to tumor growth.
Where does HER2-positive come from?
When breast tissue has extra HER2 receptors (overexpression), breast cells can multiply too quickly. The growth may become uncontrolled and lead to a tumor. Breast cancer identified as HER2-positive tends to grow faster, spread (metastatic breast cancer) and come back (recur).
The Her Pathway And Cancer
What causes amplification of the HER2 gene?
This is caused by a mutation in the HER2 (human epidermal growth factor receptor 2) gene. When the HER2 gene mutates, it causes cells in the breast to grow and divide at an uncontrolled rate, leading to tumor growth.
Where does HER2-positive breast cancer come back?
Lymph nodes near the breast tend to be the next place cancer cells go. From there, cancer cells can travel to other parts of the body farther from the breast. About one in every five breast cancers are HER2-positive. This means they have extra copies of a gene that makes the HER2 protein.
Does HER2-positive come back?
HER2-positive breast cancer is more aggressive and more likely to recur, or return, than HER2-negative breast cancer. Recurrence can happen anytime, but it usually takes place within 5 years of treatment. The good news is that recurrence is less likely now than ever before.
Does HER2-positive mean metastatic?
Since this protein can make cancer cells grow more quickly, it's natural to worry that your HER2-positive breast cancer might spread, or “metastasize.” If breast cancer spreads to other parts of your body, doctors call it “metastatic.” That means it's at a more advanced stage than if it's only in your breasts.
Is HER2 breast cancer curable?
HER2-positive breast cancer is highly curable because of the availability of these HER2-targeted therapies, so we treat patients fairly aggressively upfront to reduce the risk of them experiencing a stage IV recurrence.
Her2 In Gastric Cancer
Where does HER2 occur?
The HER2 receptor is a 1255 amino acid, 185 kD transmembrane glycoprotein located at the long arm of human chromosome 17 (17q12) . HER2 is expressed in many tissues and its major role in these tissues is to facilitate excessive/uncontrolled cell growth and tumorigenesis [7–9].
What is the survival rate of HER2-positive breast cancer?
The survival rate at four years among women with HR+/HER2− is estimated to be 92.5%, followed by HR+/HER2+ at 90.3%, HR−/HER2+ at 82.7%, and HR−/HER2− at 77.0% . The HER2 (human epidermal growth factor receptor 2) oncogene is positive in about 20% of primary invasive breast cancers .